Endocrine Abstracts

We have proposed twelve years ago that bone mass accrual, energy metabolism and reproduction must be coordinately regulated by hormones that would appear during evolution with bone. This hypothesis has been tested and verified in several ways one of them being to show that osteocalcin, the most osteoblast-specific secreted protein, is a hormone that regulates insulin secretion, glucose homeostasis, energy expenditure and male fertility. The metabolic function of osteocalcin ha...